Amaç: Bu çalışmada çeşitli klinik örneklerden izole edilen stafilokokların antibiyotik direncinin saptanması
amaçlanmıştır.
Yöntem: Çalışmaya, klasik yöntemlerle tanımlanan 274 Staphylococcus. aureus (S. aureus) ve 172 koagülaz
negatif stafilokok kökeni alınmıştır. Antibiyotik direnci, penisilin, metisilin, eritromisin, klindamisin, kotrimoksazol,
siprofloksasin, vankomisin ve fusidik aside karşı Kirby-Bauer disk difüzyon yöntemi ile
araştırılmış, metisilin direncinin saptanmasında oksasilin diski kullanılmıştır.
Bulgular: Toplam 274 Staphylococcus aureus kökeninin % 92.3'ü penisiline, %10.9'u metisiline, % 21.5 'i
eritromisine, % 14.8'i klindamisine %15.8'i ko-trimoksazole, % 7.3'ü siprofloksasine, % 5.7'si fusidik aside
dirençli bulunurken, 172 koagülaz negatif stafilokok kökeninin%84.2'si penisiline, %38.8'i metisiline,%54.8'i
eritromisine, % 44.4'ü klindamisine, %42.2'si ko-trimoksazole, % 25'i siprofloksasine, % 28.1'i fusidik aside
dirençli bulunmuştur.Vankomisin direncine rastlanmamıştır.
Sonuç: Koagülaz negatif stafilokok kökenlerinin S. aureusa göre antibiyotiklere daha yüksek oranda dirençli ve
tüm stafilokok kökenlerinin vankomisine duyarlı olduğu saptanmıştır.
Objective: The aim of this study was to detect the antibiotic resistance of staphylococci strains which were isolatedfromvarious clinical specimens.
Methods: This study included 274 Staphylococcus aureus (S. aureus) and 172 coagulase negative staphylococci strains which were identified with classical methods. Antibiotic resistance of strains to penicilline, methicillin, erythromycin, clindamycin, co-trimoxazole, ciprofloxacin, vancomycin and fucidic acid were investigated by Kirby-Bauer disc diffusionmethod, while in the detectionofmethicilline resistance oxacilline discs were used.
Results: Amongthe274 S. aureus strains, 92.3% werefoundresistantto penicilline, 10.9% to methicillin, 21.5% to erythromycin 14.8% to clindamycin, 15.8% to co-trimoxazole, 7.3% to ciprofloxacin, 5.7% to fucidic acid. Among 172 CNS strains 84.2% were found resistant to penicilline, 38.8% to methicillin, 54.8% to erythromycin, 44.4% to clindamycin, 42.2% to co-trimoxazole, 25% to ciprofloxacin and 28.1% to fucidic acid. Vancomycin resistance was not detected
Conclusion: In this study we found that strains of coagulase negative staphylococci were much more resistant than S. aureus to antibiotics and all staphylococci were susceptible to vancomycin.
