http://hdl.handle.net/11607/1795 Tue, 07 Apr 2026 16:20:33 GMT 2026-04-07T16:20:33Z http://hdl.handle.net/11607/2316 Title: Sistemik lupus eritapatozus-sekonder antifosfolipid sendromu Authors: Yavaşoğlu, İrfan Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/11607/2316 2012-01-01T00:00:00Z http://hdl.handle.net/11607/1977 Title: Yağ dokusunun işlevsel sırları Authors: Cesur, Gökhan; Gökçimen, Alpaslan Abstract: Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ. Adipose tissue plays a critical role in energy homeostasis, not only in storing triglycerides, but also by secreting adipokines that control feeding, thermogenesis, immunity, and neuroendocrine function via responding to nutritional, neural, and hormonal signals. Adipose tissue secretes bioactive peptides, termed ‘adipokines', which act locally and distally through theirautocrine, paracrine and endocrine effects. Adipokines include hormones such as leptin, adiponectin, resistin, tumor necrosis factor-alpha, interleukin-6, visfatin, apelin, adipsin, acylation stimulating protein, plasminogen activator inhibitor-1, proteins of the renin-angiotensin system, metallothionein and fasting-induced adipose factor. There is already considerable evidence of links between increased production of some adipocyte factors and the metabolic and cardiovascular complications of obesity. Adipose tissue excess or obesity, particularly in the visceral compartment, is associated with insulin resistance, hyperglycemia, dyslipidemia, hypertension, and prothrombotic and proinflammatory states. The aim of this review presents an overview of the endocrine functions of adipose tissue. Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/11607/1977 2012-01-01T00:00:00Z http://hdl.handle.net/11607/1976 Title: Perkütan nefrolitotomi sonrası uzamış idrar sızıntısının tedavisinde farklı bir yöntem Authors: Göcük, Adnan; Göktuğ, Göksel; Tuygun, Can; Alışır, İnan; İmamoğlu, Abdurrahim Abstract: The prolonged urinary leakage after percutaneous nephrolithotomy is a very rarely encountered complication. Mostly it occurs due to ureteral edema, stenosis or obstruction by residual stones. Generally minimal invasive procedures, such as J-J stent application, are satisfactory for the treatment. However, invasive therapy methods such as ablation or excision of nephrocutaneous tract, are recommended for the urinary leakage, which is resistant to this treatment. In this study we are presenting the minimal invasive method, which is applied to two patients with prolonged urinary leakage, who were resistant to the standard treatment methods after percutaneous nephrolithotomy. Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/11607/1976 2012-01-01T00:00:00Z http://hdl.handle.net/11607/1972 Title: Memenin paget hastalığı olgu sunumu Authors: Soyder, Aykut; Özbaş, Serdar; Taşkın, Füsun; Uslu, Meltem; İlkören, Saime; Erkuş, Muhan Abstract: Our case is a twenty-eight-year-old female lady who admitted to dermatology clinic of our university hospital with itchy lesions on her nipple-areolar complex of her right breast. She had these symptoms and signs for nearly two years and these lesions did not respond to topical treatment. Punch biopsy of the lesion revealed Paget's disease of the breast and the patient was referred to general surgery department. A sharply demarcated erythematous lesion with yellowish crusts were found at the nipple-areolar complex of right breast. No lumps were palpated in both of the breast and axillary examination was normal bilaterally. Mammography of right breast revealed pleomorphic microcalcifications with suspicious features of malignancy in the upper outside quadrant of the breast. Vacuum-assisted biopsy was performed and histopathological examination revealed İntraductal carcinoma. Skin sparing mastectomy and an immediate breast reconstruction with a Becker prosthesis was performed. The incidence of Paget disease below the age of thirty and the clinicopathological features of the disease were discussed in this case report. Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/11607/1972 2012-01-01T00:00:00Z